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TESTOSTERONE SHOCK THERAPY MAY BE AN EFFECTIVE PROSTATE CANCER TREATMENT


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 23 August 2020
Testosterone Therapy is popular among American Men, but it's not for everyone. For example, Testosterone exacerbates Prostate Cancer. Almost 200,000 men are diagnosed with Prostate Cancer each year. Researchers continue to search for innovative ways to treat Prostate Cancer effectively. A study from 2016 investigates a treatment method that may seem counterintuitive—Testosterone Shock Therapy. One patient in this study experienced complete remission resulting from treatment.

Testosterone Normally Makes Prostate Cancer Worse

Under normal circumstances, Testosterone exacerbates Prostate Cancer, but a high-dose of Testosterone appears to kill the Prostate Tumor. In order to eliminate Prostate Cancer cells, researchers alternated between delivering high doses and extremely low doses of Testosterone. This treatment is also known as Bipolar Androgen Therapy. Intriguingly, researchers do not currently fully understand how this works, but the results are readily apparent. The long-term goal is to learn the mechanisms behind this new treatment and figure out how best to include Testosterone Shock Therapy, among other treatment options.

Bipolar Androgen Therapy Helps Patients Grapple With Prostate Cancer

Patients underwent three phases of alternating High/Low Testosterone exposure. This pattern overloads Prostate Cancer Cells then starves them. It's hypothesized that this alternating pattern helps kill off the cells faster than simply cutting them off from their fuel source. Each Testosterone Cycle consisted of a single injection of High-Dosage Testosterone every four weeks. During this same period, they received medication to shut down the natural production of Testosterone. The easiest way to monitor Prostate Cancer activity is by measuring Prostate Specific Antigen (PSA) Levels. The higher that PSA Levels are beyond baseline, the more aggressive the tumor. Among patients in the experiment, 47 men experienced lower PSA Count due to Testosterone Shock Treatment. The one lucky patient with total remission had PSA Levels fall to zero for at least 22 treatment cycles. Shock Treatments helped many patients stabilize their Prostate Cancer, halting its progression. It's clear that this treatment can help at least some patients significantly reduce the mortality risk associated with Prostate Cancer.

Bipolar Androgen Therapy Alternative to Androgen Deprivation Therapy

For decades, it's been supposed that Testosterone is the primary reason that Prostate Cancer gets out of hand. Indeed, treatments that shut down Testosterone Production or block Testosterone Activity have proven useful and effective. It's believed that Bipolar Androgen Therapy works because it interrupts the proliferation of Prostate Cancer Cells by disrupting cellular division. The alternating feast/famine Testosterone Cycle appears to breakdown the DNA of these rogue cells.

TESTOSTERONE AND OTHER SEX HORMONES IMPACT ASTHMA RESPONSE DEPENDENT ON SEX


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 21 July 2020


Many conditions affect men and women differently. One of these conditions is asthma. It has long been known that pre-pubertal males tend to have more issues with asthma than females of the same age, but the underlying reasons why have not been so clear.

Recently, researchers from Johns Hopkins have explored the effects of Testosterone concerning asthma. It's critical to understand how men and women differ physiologically because it leads to different risks and different factors that impact potential treatment options.

While this study was conducted in mice, its results are hypothesized to be transferrable to humans. The research was published via the Journal of Immunology last October. While women are less likely to experience asthma than men in adulthood, Testosterone activated inflammation receptors in the lungs in response to exposure to an allergen known as ovalbumin. Obviously, these results give some mixed messages.

Asthma Risk Dependent on Age and Sex

Asthma is an interesting condition because its prevalence changes among males and females depending on age. Prior to puberty, boys are more liable to have issues with asthma than girls. After puberty, however, the situation changes. Then girls and women are more likely to have asthma. This is a clear example of how sex hormones lead to wellness-related sex differences. By exploring the mechanisms behind these differences, we can improve asthma diagnosis and treatment protocols.

A previous study investigated how Estrogen effected lung inflammation in mice. They found that Estrogen triggers inflammation. As we mentioned earlier, post-pubertal girls and women have a much higher incidence of asthma than men of the same age. This data led researchers to hypothesize that Testosterone would provide benefits against lung inflammation. For example, while still in experimental phases, male hormones have been prescribed as a successful treatment for women with asthma.

Mouse Testosterone Asthma Study

In order to learn more about how Testosterone impacts asthma, researchers needed mice that couldn't produce their own sex hormones. By using castrated mice, they could precisely control hormone levels using Testosterone Implants, which slowly and steadily release hormones.

Researchers also had to simulate asthmatic allergic reaction in the mice, because mice don't normally experience allergic asthma. Researchers aerosolized albumin to trigger a lung reaction similar to what humans experience when they have an asthma attack.

Testosterone and Lung Inflammation

Lung Inflammation is triggered by specific immune cells known as Alveolar Macrophages. These microscopic phagocytes absorb and break down debris in the lungs. They also trigger inflammatory activity, including the cascade of symptoms associated with an asthma attack. Researchers expected Testosterone to protect against lung inflammation in the mice.

What they discovered was more complicated. While Testosterone suppressed most markers of inflammation, it activated lung inflammation, specifically in Alveolar Macrophages. Researchers then bred male/female mice without Testosterone Receptors in their Alveolar Macrophages. Here, they discovered a critical sex-difference. Male mice had less inflammation when these receptors were deactivated. Female mice saw no such change. This means that in male mice, Testosterone is more intricately involved in how irritants trigger asthma response.

This provides evidence for why Testosterone can help women with asthma, but those results are sex-specific. This research highlights that a person's individual characteristics are very important to consider when deliberating upon treatment options.

In the future, research like this will likely lead to treatment options that differ for men and women. While an asthma attack looks the same in males and females, the mechanisms which trigger the attack clearly differ, which provides different opportunities for ideal treatment. Antihistamines and Steroids are the go-to treatment for asthma, but males with severe asthma may benefit more from an alternative form of therapy.


TESTOSTERONE THERAPY MAY BENEFIT SOME PROSTATE CANCER SURVIVORS


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 17 May 2020

Testosterone Therapy May Benefit Some Prostate Cancer Survivors

Historically, researchers and doctors hypothesized that Testosterone Replacement Therapy was associated with some risks, including cardiovascular complications, increased Prostate Cancer Risk, and other potentially dangerous health issues. On the other hand, studies published in recent years have provided a growing body of evidence that Bio-Identical Testosterone for Low-T is much safer than previously believed, even among many patients that were once considered most at-risk.

For generations, scientists have believed that Testosterone increases the likelihood and severity of Prostate Cancer. In fact, the 1941 Nobel Prize for Medicine was awarded for research which demonstrated how Testosterone Suppression positively impacted Prostate Cancer Outcomes.

A recent large-scale study calls this notion into question, however. In March, researchers produced evidence at the Congress of the European Association of Urology which suggests that certain patients with a history of prostate cancer can benefit greatly from Bio-Identical Testosterone Therapy. This study focused on patients with Prostate Cancer in remission that were at low risk of recurrence. If this research is further confirmed to be true, it will change the way that doctors think about the use of Testosterone Creams, Patches, and Injections for patients with past experience with Prostate Cancer.

Testosterone Suppression Benefits Prostate Cancer PatientsBut at What Cost?

While there is no dispute that Testosterone Suppression Treatments do protect patients from Prostate Cancer recurrence, there are serious downsides. Research published around the turn of the century unequivocably shows that, while patients have improved outcomes with regard to Prostate Cancer risk, Low Testosterone Levels significantly increase the risk of cardiovascular health issues, leading to a significant increase in mortality risk.

Our bodies are heavily reliant on hormones to maintain optimal health, and major changes in Hormone Balance can have severe and dramatic effects on wellness. Testosterone is essential for maintaining healthy metabolism and cardiovascular function. Patients treated with drugs which suppress Testosterone Levels were directly more likely to have increased deposits of body fat around the mid-section, unhealthy cholesterol levels, and complications associated with diabetes and high blood sugar. Androgen Suppression also led to a decline in quality of life related to Erectile Dysfunction and loss of libido.

Because of this collection of complicating issues, many doctors began to hypothesize that the benefits of Testosterone Therapy likely outweigh the risks for many patients at minimal risk of recurrence post-treatment.

Cal-Irvine Testosterone Study for Prostate Cancer Survivors

In a long-term study conducted from 2008-2011, Thomas Ahlering and his staff at Cal-Irvine studied the effects of Testosterone Therapy upon 152 patients treated for Prostate Cancer via robotic prostate removal. The goal was to help patients experience improved sexual health after prostatectomy. The study analyzed the health outcomes of 834 total patients. Around three years after prostate surgery, patients returned for inspection. Researchers searched for signs of Prostate Cancer recurrence as evidenced by an increase in Prostate Specific Antigen Levels. Elevated PSA Levels are the prime non-invasive indicator of prostate cancer.

Fascinatingly enough, researchers found that patients that received Testosterone Therapy were 1/3rd as likely to experience the return of Prostate Cancer. Five percent of patients undergoing Low-T Treatment showed signs of Prostate Cancer, whereas 15% of those that did not receive therapeutic Testosterone showed signs of the disease.

The significance of the Effective Treatment of Prostate Cancer with Testosterone Therapy

Thomas Ahlering was surprised by the results of the study. He only sought to confirm the safety of Testosterone for Sexual Health among Prostate Cancer survivors, but it appears that Testosterone can have a major impact on overall mortality risk. He explains that Testosterone isn't stopping the progression of Prostate Cancer, but it slows the development of the cancer, extending remission by an average of 1.5 years. This is combined with the highly beneficial impact of Testosterone upon sexual wellness, triglyceride levels, cholesterol, body composition, and insulin sensitivity.

If further study demonstrates the safety and effectiveness of Testosterone Therapy for Prostate Cancer Survivors, then Low-T Treatments may become the norm for these patients in the near future. Numerous studies published in the last decades have increased awareness of the overall safety profile of Bio-Identical Testosterone Treatments for various segments of the male population. When used appropriately and monitored closely, Low-T Therapy appears to be a potential boon for millions of aging men across America, as well as patients with issues which impair their healthy Testosterone Production.

It's important to question the perceived norms regarding Testosterone Therapy so that patients can receive the best results with the best outcomes. For now, patients who've had their prostates removed appear to be in the clear for safe and effective use of Testosterone. In the future, it is inevitable that more groups will be approved for such treatment.

Over Thirty and Interested in Testosterone Therapy? We Can Help!

If you're interested in learning more about the fantastic benefits of Testosterone Replacement for Low-T, our Licensed and Board-Certified HRT Clinic provides Free Consultation to potential clients. Our Hormone Specialists have helped men across the United States experience improved well-being and health outcomes via Testosterone Restoration. We also offer a variety of forms of Hormone Optimization designed to meet the needs of both men and women, including HGH Therapy, Sermorelin Acetate for Somatopause, Thyroid Treatments, and Physician-Mediated Weight Loss Plans.

We specialize in the treatment of Age-Associated Hormone Issues in patients thirty and older. Our goal is to restore Hormone Levels associated with early adulthood to counteract the detrimental symptoms associated with Hormone Decline and Imbalance so that patients can experience elevated quality of life. We work with Quest Diagnostics and LabCorp to extend our logistical capacity for fast and accurate assessment and treatment all across the United States. We work with reputable pharmacies that provide effective and affordable HRT Products and Services! We can help you overcome the demoralizing effects of Hormone Imbalance so that you can live a better life!


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Correctly performed testosterone therapy can be your ticket to health.

Three sided solution: Testosterone + HCG + Arimidex

If your doctor only prescribes testosterone by itself, you will probably have a rough ride. The tendency is for you to feel great the first couple months, while you increase testosterone levels, followed by a slow deterioration, once your estrogen creeps up.

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