Studies Regarding The Potential Benefits Of Resveratrol

Study Displays the Benefits of Resveratrol

Scientists have recently concluded that Resveratrol can produce significant benefits in terms of anti-aging and overall health and wellness. A recent study conducted by Harvard medical scientists confirms a long-standing hypothesis that Resveratrol is an incredibly beneficial supplemental nutrient. One of the most well-known sources of Resveratrol is red wine, although red grapes also confer the benefit, in addition to dark chocolate and other foods.

Resveratrol Increases SIRT-1 Release

This research was conducted in early March 2013 and illuminates the process by which Resveratrol interacts with human physiology. Researchers found that Resveratrol works by increasing the secretion of a hormone known as SIRT-1. SIRT-1 is intricately linked to cellular efficiency and longevity. SIRT-1 also increases the body's resistance to disease by increasing the rate of mitochondrial activity.

In addition to discovering how Resveratrol stimulates hormone production, scientists also discovered the exact genetic link that causes Resveratrol to produce its stimulative effects. The researchers also hypothesize that a number of pharmaceuticals currently in the process of clinical assessment may be able to stimulate these same benefits regarding longevity.

Researchers Optimistic about Resveratrol

The research team responsible for this discovery is incredibly excited and optimistic about the study's findings. The lead researcher, Dr. David Sinclair, explains that Resveratrol achieves something he has yet to witness from any other drug. The rate at which Resveratrol increases mitochondria metabolism is unprecedented.

Dr. Sinclair is a genetics professor at Harvard Medical School. He is also a scientific consultant and one of the founders of Sirtris, a company related to the pharmaceutical giant GlaxoSmithKline. Sinclair goes on to say that very few drugs have the capacity to increase cellular metabolism and that most drugs that interact at this level actually block or depress this form of metabolism.

Resveratrol is an Anti-Oxidant as Well as a Phytoalexin

Although Western Scientists are just beginning to learn about Resveratrol, it is a natural chemical, most commonly in cocoa and grapes. Resveratrol has been used as an herbal treatment in countries such as China and Japan for centuries. Resveratrol belongs to a potent class of compounds known as antioxidants that preserve cellular health at the molecular level, safeguarding the cells from outside damage and damage caused by internal processes of organic function.

Resveratrol not only has antioxidant capabilities but also produces anti-inflammatory and immune-strengthening benefits. Resveratrol belongs to a classification known as Phytoalexins, a group of microscopic compounds that prevent microbes from establishing a presence on plants. In addition, Phytoalexins can increase plants' resiliency, preserving them from dangers such as environmental change, infection, and excess sunlight.

Other Benefits of Resveratrol

Resveratrol is connected to several different preservative benefits in humans. It safeguards the body against both diabetes and obesity while having an immensely positive effect on the cardiovascular system. Regarding the heart and the bloodstream, Resveratrol has been proven to alleviate excess blood clotting, normalize LDL Cholesterol levels, open up blood vessels, and reduce blood pressure. Resveratrol also seems to have a stimulative effect on Nitric Oxide production.

Resveratrol Controversy: Was Early Resveratrol Research Falsified?

Although studies in the past pointed to the potential benefits of Resveratrol, earlier researchers were accused of falsifying results to make Resveratrol look more beneficial than it is. In early 2013, rumors began to fly that Dr. Dipak Das, the author of several studies regarding Resveratrol, was serially fluffing up the results. The results of this study vindicate Dr. Das and provide further evidence that Resveratrol produces specific benefits in ways that have not been replicated elsewhere.

There were two primary sources of conflict regarding Dr. Das' study. The first conflict was primarily regarding the data itself. Many researchers question whether Resveratrol was actually increasing the release of SIRT-1 directly or if some other conflicting influence was actually producing the displayed benefit.

The second conflict inferred something more sinister. Some scientists were so awed by the level of SIRT-1 stimulation that they did not believe the results could be produced without outside tampering. They believed that the vastly increased SIRT-1 activation resulted from researcher manipulation rather than a natural biological process.

New Resveratrol Study Resolves Controversy

In this Harvard Resveratrol Study, researchers concluded that high levels of Resveratrol are likely to be incredibly beneficial in preserving the health of aging men and women. Dr. Sinclair explains that he and his staff worked for six years to prove that Resveratrol does indeed increase SIRT-1 production. They had their first confirmation in 2006, using laboratory mice to show proof of benefit.

After 2006, the goal of research went from proving the impact of Resveratrol to uncovering the underlying genetic component that causes Resveratrol to activate within the human body. Surprisingly, the conclusion that the researchers came to was incredibly clean-cut.

How Does Resveratrol Work?

In attempting to showcase the link between SIRT-1 and Resveratrol, researchers found that Resveratrol was chemically very similar to a few different natural amino acids, including Tryptophan, which is common in certain meats and food products such as turkey. After discovering a potential link between Tryptophan and Resveratrol, they attempted to activate SIRT-1 molecules in a laboratory setting to establish the link more fully. They were successful.

After making this link, Dr. Sinclair and his research team studied two thousand separate mutations of the SIRT-1 gene to find out exactly how Resveratrol functioned. As they studied these various mutations, they discovered one form of mutated gene that did not respond to Resveratrol stimulation.

After pinpointing the location of Resveratrol activation, they were able to go into normal genes and turn off that single gene in an otherwise perfectly normal genetic code. Scientists cultured skin and muscle cells that had the gene for Resveratrol turned off. Then, they tested the culture with Resveratrol and other pharmaceuticals that impacted the same gene. In control cells, Resveratrol produced its hypothesized stimulatory function. Experimental cells no longer benefited from Resveratrol exposure.

Dr. Sinclair's Resveratrol Study Answers Many Questions

Dr. Sinclair says that this was the experiment that connected all the dots. After conducting this experiment, it became perfectly clear that Resveratrol does, in fact, stimulate SIRT-1 secretion. Now that the researchers have made the connections, this paves the way for further scientific study to examine how Resveratrol stimulates SIRT-1 production and re-engineer the hormone to produce an even stronger stimulative effect.

The Doctor is not only interested in producing a more robust and stimulative form of Resveratrol. He wants to learn more about its benefits and commit to further scientific study to examine its capacity to benefit healthy individuals.

Resveratrol Research Enlightens Our Understanding of Aging

Therapeutic Resveratrol Treatment is very near on the horizon, and the benefits seem to be astounding. These findings regarding Resveratrol provide further evidence that the aging process is more complicated and less inevitable than we previously imagined. Every year, breaking the threshold of 100 years will get easier. Although some aspects of aging are irreversible, it is becoming clear that more and more conditions that were once thought to be the result of aging are simply the result of hormone imbalance and other medical issues that are damaging health.

One day, we may even find that the majority of aging symptoms are the result of malfunctions of this sort. Evolution was not designed to produce an Ageless Man, but it is becoming clear that there are numerous ways that we can chemically and biologically alter our personal physiology to alter and prolong the normal common track of human life and existence.

Many Scientists are Intrigued by the Possibilities of Resveratrol

Many in the scientific community share Dr. Sinclair's enthusiasm about Resveratrol. Dr. Leonard Guarente, another Sirtris science consultant and MIT biologist, believes that Resveratrol is the real deal. He believes that Resveratrol research and development will inevitably lead to profoundly beneficial results (and financial success for those who invest in Resveratrol).

Resveratrol Converting Skeptics

The findings of this study are so clear and confident that they are even converting former skeptics and detractors into believers. Dr. Brian Kennedy, CEO and President of the Buck Institute for Research on Aging, was once incredibly skeptical concerning initial Resveratrol research because he did not believe that positive results in yeast would carry over into human physiology. Now that early research has been supported and shown that Resveratrol indeed activates human cells, Dr. Kennedy has changed his mind about Resveratrol and is optimistic that further research will yield real benefits.

It is becoming increasingly clear that despite how different we seem, living organisms share an immense, awe-inspiring level of biological continuity.

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