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B12: people who had higher vitamin B12 levels were six times less likely to experience brain shrinkage


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The Importance of B12 for Energy and Health

Vitamin B12 is one of many important and vital nutrients used by the body to foster optimal health. Vitamin B12 is a vitamin which encourages peak function of blood cells while also maintaining the health of the nerves.

The vitamin also has another function central to human life: it is one of the necessary materials for the construction of DNA molecules, which store all of the data which contribute to human development. This nutrient also helps keep the body energized and strong, and Vitamin B12 Deficiency can lead to a condition known as Megaloblastic Anemia.

How Does the Body Absorb B12?

Vitamin B12 is drawn directly from the food that we eat. It is absorbed through a relatively simple process. The first step takes place within the stomach. The stomach contains powerful hydrochloric acid which has the ability to break down the foods we eat and render them into simpler parts.

When consumed as part of a meal, Vitamin B12 is connected to proteins in the food that we eat, and hydrochloric acid breaks the bonds which connect Vitamin B12 to the protein. After the Vitamin B12 Molecule has been freed, it then reacts with another molecule known as Intrinsic Factor.

Intrinsic Factor is a protein which bonds with B12, allowing the nutrient to be taken in by the body. There are some people that actually lack the ability to make Intrinsic Factor, which causes them to absorb very low levels of B12. This condition is known as Pernicious Anemia.

How Much B12 Does the Body Need?

The human body requires Vitamin B12 at all stages of life, but the requirements vary dependent upon age. Children need an amount which slowly grows from 0.4 micrograms in the first six months of life, to 1.8 micrograms per day at 13 years. From 14 years old through adulthood, the body has a relatively steady requirement for B12 which is around 2.4 micrograms.

Women that are pregnant need a little more in order to promote healthy fetal development, around 2.6 micrograms. Women that are breastfeeding need the highest levels, around 2.8 micrograms. This makes sense, because early in life, the child is completely dependent upon breast milk for nutrition, so the mother must increase her own production to compensate.

What Are the best Sources of Vitamin B12?

Vitamin B12 is one of a number of nutrients that are only available to human beings through either animal or synthetic sources. Below are a number of sources of Vitamin B12:

  • Milk Products

  • Eggs

  • Poultry

  • Meat

  • Fish

  • Some Yeast Products

  • Supplements

  • Fortified Cereals

  • Other Fortified Foods

  • Clams

  • Liver

The final two suggestions, Liver and Clams, contain the most significant levels of B12. B12 is processed by the liver in animals that cannot produce it naturally, and it is synthesized in herbivores that do have the capability to make their own Vitamin B12 from plant material. As a result, aside from clams, liver is the single best source for Vitamin B12.

What is Vitamin B12 Deficiency?

A deficiency of Vitamin B12 brings about a rather particular set of symptoms, among which are:

Physical Symptoms of B12 Deficiency

  • Weight Loss

  • Appetite Suppression

  • Constipation

  • Weakness

  • Fatigue

  • Megaloblastic Anemia

Neurological Symptoms of B12 Deficiency

  • Tingling and Numbness in the Feet and Hands

  • Soreness of the Tongue or Mouth

  • Cognitive Decline

  • Dementia

  • Confusion

  • Depression

  • Balance Issues

It should be noted right away that a deficiency in Vitamin B12 can cause neurological symptoms, even if the physical symptoms do not manifest themselves. Some of the neurological damage resulting from B12 Deficiency is also irreversible, so it is incredibly important to diagnose and treat Vitamin B12 Deficiency as soon as possible.

Although the overall need for B12 is lower for children than adults, severe issues can occur as a result of prolonged Vitamin B12 Deficiency early in life. B12 Deficiency can cause many problems for infant patients.

The Symptoms of Childhood B12 Deficiency include:

  • Megaloblastic Anemia

  • Slow Development

  • Disorders of Movement

  • General Failure to Thrive

If you notice any of these symptoms, it is important to make an appointment with a pediatrician as soon as possible. The symptoms of Vitamin B12 Deficiency share similarities to other developmental disorders, and it is important to get an appropriate diagnosis as soon as possible.

How is Vitamin B12 Deficiency Cured?

Generally, the way to resolve B12 Deficiency is through direct intervention with Injections of Vitamin B12. B12 Injections allow for maximum absorption, because B12 is delivered directly to the body, bypassing more limited digestive absorption. If an immediate injection is not deemed necessary, a physician may recommend taking Vitamin B12 Orally in high doses in order to resolve the Deficiency.

One study compared the effectiveness of Oral B12 versus B12 Injections. Researchers found that oral Vitamin B12 was able to replicate the effectiveness of injections over time. The optimal way to restore B12 through oral supplementation was to take high doses of B12 (2000 micrograms) every day initially, then cutting the dose in half. After cutting down to half doses, it was eventually possible to cut down to weekly, and finally monthly, doses, before simply allowing the patient to proactively make steps to maintain healthy levels of Vitamin B12.

Although both forms of supplementation are effective, the ability of the patient to absorb the nutrient through the digestive tract, and the severity of the deficiency will be the most significant factors which lead the physician to take the appropriate course of action.

How are B12 Shots Injected?

Like Testosterone Injections, B12 Injections are Delivered Intramuscularly.

How are Vitamin B12 and Folic Acid Connected?

Individuals that consume a high level of Folic Acid in their diet can make the dangerous symptoms of severe Vitamin B12 Deficiency less apparent. Folic acid has the ability to resolve Megaoloblastic Anemia without resolving the underlying neurological complications of the condition.

There are even studies which provide evidence that high levels of folate in the blood stream can eventually make anemia worse and amplify the neurological issues related to B12 Deficiency, increasing the risk of cognitive decline.

This combination of Folic Acid Overload and B12 Deficiency can lead to permanent nerve damage. Because of this significant risk, healthy men and women should take no more than 1,000 micrograms of Folic Acid per day.

Who is at Greatest Risk of B12 Deficiency?

There are a number of issues which can lead directly to Vitamin B12 Deficiency. These causes include:

  • Pernicious Anemia

  • Lack of B12 in the diet

  • Inability to appropriately absorb B12

  • Post-surgical inability to properly absorb Vitamin B12

Although these are the four leading causes of Vitamin B12 Deficiency, there are many cases in which the cause of B12 Deficiency is unclear.

Who is Most at Risk of B12 Deficiency?

Aging Adults

As men and women grow older, the odds of developing Vitamin B12 Deficiency grow. There is a condition known as Atrophic Gastritis, which causes the stomach to produce abnormally low levels of Hydrochloric Acid. As a direct result of this, B12 Absorption drops.

This condition affects ten to thirty percent of older men and women. This change in hydrochloric acid production can also change the composition of gut flora, leading to the formation of bacteria which consume Vitamin B12 to propagate, reducing the amount available to the body itself.

Because this disorder reduces the body's ability to break down food sources of Vitamin B12, it can be easily treated through direct supplementation. In addition to this, foods fortified with B12 are also a useful source, because the synthetic form of B12 present in most fortified foods is easier to absorb than natural B12 for these individuals.

Because of the risk of Atrophic Gastritis, physicians recommend getting B12 from either fortified foods or supplements after the age of fifty. It should also be noted that elderly men and women that have this disorder should intake more Vitamin B12 than Recommended Daily Values Suggest.

People with Pernicious Anemia

Pernicious Anemia is a medical issue which afflicts between one and two percent of adults over fifty. The main issue with regard to these patients is they either produce no or little Intrinsic Factor, which is necessary in order for the digestive system to properly absorb B12.

The most effective way to treat this medical condition is through the use of Vitamin B12 Injections. Injections bypass the need for Intrinsic Factor and supply usable Vitamin B12 directly to the body. It may also be possible for some patients to use high doses of oral B12 in lieu of Vitamin B12, because around one percent of orally ingested Vitamin B12 can be absorbed even without the agency of Intrinsic Factor.

People with General Gastrointestinal Problems

There are certain diseases of the small intestine and stomach which complicate Vitamin B12 Absorption, including Crohn's Disease and Celiac Disease. These complications can prevent patients from getting the Vitamin B12 that they need from a normal diet.

Because of this inherent deficiency, some individuals with diseases such as these can experience very subtly decreased cognitive ability as a direct result of childhood Vitamin B12 Deficiency. In addition to this, they can also eventually suffer from dementia or Megaloblastic Anemia. For this reason, it is undeniably important for anyone with gastrointestinal disorders to evaluate their B12 Levels on a regular basis as a preventative measure against these conditions.

People that Have Undergone Surgery of the Stomach or Small Intestine

Certain surgeries can impact the digestive system's ability to absorb healthy levels of Vitamin B12. Individuals that undergo gastric bypass surgery or other weight loss surgeries often find that their ability to absorb Vitamin B12 Decreases as a result of less Intrinsic Factor and Hydrochloric Acid release by the stomach.

Any surgery which removes part or all of the stomach also leads to this issue. This has particular effect upon the body's ability to absorb natural forms of B12. Removal of the end of the small intestine, known as the distal ileum, can also inhibit or stop B12 Absorption. Anyone that goes under the knife for gastrointestinal surgery of any kind should be regularly monitored for any nutritional complications.

Vegetarians

Vegans and vegetarians are at a high risk of developing B12 Deficiency if they are not conscientious about their diet. The only natural sources of B12 for human beings are derived from animal products, and, unless vegetarians look to supplemental sources of B12, it will be impossible to get the necessary Vitamin B12 for optimal health.

Vegetarians that still use milk products or eat eggs do not have this same levels of risk, and pescatarians can easily get the B12 they need from fish sources. Luckily for vegetarians, there are now a number of fortified sources of B12, the most common of which is contained within many breakfast cereals.

Lactating and Pregnant Vegetarians, as well as their Infants

During pregnancy, the fetus receives necessary Vitamin B12 through the placenta. After being born, B12 is received through the breast milk. If infants are breastfed by vegetarian mothers, they often receive abnormally low levels of B12, which can hinder their optimal development. If B12 Deficiency is not caught very early, it can cause very serious and potentially life-long problems.

American Dieticians very strongly suggest that both lacto-ovo vegetarians and vegans take ample supplemental B12 during pregnancy in order to ensure the health of the infant. They should also ask their doctors about providing their young children with B12 Supplements to eliminate all potential risk.

Connections Between Vitamin B12 Deficiency and Negative Cardiovascular Outcomes

Among first world countries, heart disease is usually the number one cause of death. In developing countries, the threat of Heart Disease continues to increase as other easily preventable causes of death are eliminated, and changes in diet and lifestyle promote increased odds of the condition. Some major risk factors of Heart Disease are:

  • Diabetes

  • Obesity

  • Low HDL Cholesterol

  • High LDL Cholesterol

  • Hypertension

  • High Homocysteine Levels

Vitamin B12 and Homocysteine

Homocysteine levels are strongly associated with Vitamin B12 Consumption. Homocysteine is an amino acid compound that is necessary for a healthy cardiovascular system, the problem is that a lot of individuals produce way too much of it.

Excessively high Homocysteine production causes a number of issues which reduce the function of the heart and increase the risk of heart complications. It encourages the formulation of clots, prevents proper vasodilation, and changes the muscular composition of veins and arteries. It also causes the breakdown of fat in the blood stream, releasing dangerous free radicals into the body.

Vitamin B6, Folate, and Vitamin B12 are vitally important in the metabolism of Homocysteine. In the result of B12 Deficiency, Homocysteine production can rise in a dangerous manner. Vitamin B12 Supplementation in combination with Folate Supplementation has been shown to have an ameliorative effect on Homocysteine Production, encouraging a reduced risk of stroke.

To this point, the evidence is incomplete in regard to whether providing B12 Supplementation improves other aspects of Cardiovascular Health in at-risk patients. This does not, however, diminish the importance of maintaining healthy B12 consumption throughout the lifespan, because, although Vitamin B12 may be limited in its ability to treat heart problems, proper use of B12 throughout the lifespan can help reduce the risk of developing these complications in the first place.

Vitamin B12 and the Brain

B12 May Protect the Brains of the Elderly

In a recent study conducted by scientists at Oxford, a strong correlation was found between the overall volume of the brain, and healthy Vitamin B12 consumption. In this study, researchers collected data from 107 participants. These participants ranged in age from sixty one to eighty seven. None of the subjects displayed any signs of cognitive decline or issues with memory. The median age of the subjects was seventy three, and 46% of the participants were men.

The scientists then proceeded to draw blood in order to assess the Vitamin B12 levels of each patient. Vitamin B12 is found in highest concentrations in milk, fish, and meat. In addition to blood testing, each subject also underwent annual MRI brain scans in order to visually assess the condition of the brain. They also received a yearly physical and memory evaluation.

Among the 107 men and women, none of them were found to have a Vitamin B12 Deficiency. Researchers took the data that they compiled from this study and compared it to studies of patients which suffered from Vitamin B12 Deficiency. They discovered that men and women with Vitamin B12 Deficiency were six times more likely to have smaller brain volumes than patients that had healthy levels of B12.

Although they were able to establish this link, the scientists were not able to provide evidence regarding the impact of brain size on cognitive impairment.

Maintaining Healthy Vitamin B12 Levels Helps Prevent Cognitive Issues Later in Life

The project leader, Anna Vogiatzoglou, explains that there are a lot of different factors which contribute to adverse changes in the condition of the brain, but her study shows that there is a powerful connection between Vitamin B12 and the preserving the size of our brains.

Although her study did not have the ability to establish psychological and cognitive changes related to changes in brain size with age, she hypothesizes that making sure that we get enough Vitamin B12 throughout our lives is a thoughtful and productive step in preserving proper and healthy brain function later in life. By taking this healthy and conscientious step, there is a significant chance that we can preserve our memory more effectively with age.

Although the study provides a positive link in regard to Vitamin B12 Levels and Brain Shrinkage, the study did not analyze the effect of Vitamin B12 Supplementation as a preventative treatment for elderly patients.

It appears that, like the connection between Cardiovascular Health and Vitamin B12, there is a limited ability for Vitamin B12 to be a treatment for conditions related to untreated Vitamin B12 Deficiency, but maintaining healthy Vitamin B12 Levels throughout the lifespan can help prevent significant issues later in life.

Does Excessive B12 Supplementation Lead to any Health Risks?

Vitamin B12 has an extremely low capacity for toxicity. Because of this, there is little to no risk of complications resulting from the over-consumption of the nutrient. Vitamin B12 is water-soluble, and nutrients of this type are generally absorbed by the body as needed, then released into the urine. Fat soluble Vitamins generally carry a certain risk of overdose (Vitamin A being one particular example).

Vitamin B12 Final Thoughts

As you can see, it is vitally important to make sure that your body gets a healthy dose of Vitamin B12. If you are conscientious, this is one of the best ways to preserve your cognitive health deep into old age.

There is really no reason to experience Vitamin B12 Deficiency, unless your body is beginning to have trouble processing the nutrient. If you have a feeling you aren't getting enough Vitamin B12 in your diet, we actively encourage you to seek out a supplement. There is absolutely no downside, and it can have a tremendously positive impact upon your cardiovascular system, neurological system and general energy levels.

30 September 2013

L-Carnitine: Improves Cognitive Function in Centenarians

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L-Carnitine proven to reduce physical and mental fatigue while improving cognition in those over 100 years of age.

The American Journal of Clinical Nutrition has recently released data from clinical research conducted by Italian scientists regarding L-Carnitine as a medical treatment. The study was financed in order to explore the potential benefits of L-Carnitine in elderly patients. The results of the study indicate that L-Carnitine has the ability to significantly improve cognitive ability and reduce fatigue in patients of one hundred or more years of age.

How Does the Body Get L-Carnitine?

L-Carnitine is naturally produced in the human body, but like many other vital hormones and proteins, endogenous production of this vital protein declines naturally as a result of the aging process. In a healthy individual, the human body contains somewhere between twenty and twenty five grams of this molecule. L-Carnitine is most abundant in cells and organs across the body that have very high metabolic requirements. These organs include the brain, the heart, muscles, immune cells, sperm, and nerves.

Without a sufficient supply of L-Carnitine, the human body cannot sustain itself. Although a large portion of L-Carnitine that human beings utilize comes from the diet, the human body has the ability to synthesize this protein when the body has an adequate amount of the amino acids methionine and lysine. In addition to the presence of these amino acids, the body also needs the nutrients iron, Vitamin B3, Vitamin B6, and Vitamin C in order to create this hormone internally. Without proper nutrition, the human body is unable to produce its own store of L-Carnitine and health will deteriorate as a result.

L-Carnitine is Necessary for Healthy Metabolism

L-Carnitine is vitally important in maintaining a healthy level of cellular metabolism, and if the body is deficient in this vital hormone then the body's protective physiological processes slow down as well. Like Human Growth Hormone Deficiency, L-Carnitine Deficiency plays a major role in an increased rate of aging and decreased rehabilitative ability. L-Carnitine Deficiency is widely believed to be one of the primary factors which induce severe fatigue in older patients, and there is great hope that L-Carnitine can be used in order to amplify low-energy levels in geriatric patients.

L-Carnitine Study Parameters

This particular study featured 46 women and 24 men ranging in age from 100 to 106. All of these patients were chosen based on their report of experiencing significant exhaustion after even the most minor levels of physical activity. This was a tightly controlled study in which half of the patients were randomly selected to ingest two grams of L-Carnitine daily while the control group unknowingly took a placebo. The 70 patients were monitored over the course of 6 months while taking daily doses of either L-Carnitine or placebo.

Every patient underwent a routine physical both before and after the 6 month period of treatment in which their muscle mass, total body fat, and BMI were recorded. Once each month, the researchers drew blood samples in order to monitor L-Carnitine and Cholesterol levels as well as a number of other factors. In lieu of a more analytical method, patients were asked to self report levels of physical and mental fatigue and exhaustion.

The Similarity of Fatigue and Pain

Fatigue is similar to pain in that the experience of these two negative phenomena are completely relative to the perception of the patient and not to any testable analytic. Before and after the monitoring period, each patient was evaluated for overall cognitive function. Although fatigue is impossible to accurately measure, cognitive testing can scientifically prove that self-assessed fatigue limits overall cognitive ability. The physical effects of fatigue were monitored via a 6 minute session of light cardiovascular activity.

L-Carnitine Study Results

Out of the seventy patients who participated in this study, eight of the patients died before the six month testing period was complete. Three patients in the experimental group did not survive the testing period, while five patients in the placebo group died. This left 62 patients who provided a full set of usable data. Over the course of six months of therapy, the experimental group did indeed experience boosted levels of L-Carnitine in the blood stream. As a result of this increase in L-Carnitine Levels, the patients experienced a number of positive benefits, including:

  • Measurable decrease in mental and physical fatigue

  • Reduction in severity of mental and physical fatigue

  • Increases in muscle mass

  • Reduced levels of fat

  • Decreased cholesterol levels

  • Improved performance on cognitive tests

  • Increased ability to withstand light physical activity

How does L-Carnitine Benefit the Body?

It is well known in the medical community that L-Carnitine is vital for the oxidation of long-chain fatty acids by cellular mitochondria. It is believed that increased L-Carnitine levels improve the ability of the mitochondria to metabolize fatty-acids, thus causing a number of physiological benefits in the experimental participants, manifested both physically and cognitively.

This evidence also suggests that increased levels of L-Carnitine help the body utilize glucose more efficiently, allowing the body to sustain activity for a longer period of time. In addition to this, L-Carnitine preserves muscular glycogen, which is the immediate energy source for the muscles. All of this combines to preserve the rate at which ATP is efficiently expended in order to support physical activity. In patients with L-Carnitine Deficiency, ATP stores are burned up more quickly, causing these individuals to experience fatigue and exhaustion more quickly, inhibiting their ability to engage in cardiovascular activity dependent upon the severity of the deficiency.

Elderly Patients Desperately Need L-Carnitine

By the age of 100, Endogenous L-Carnitine levels are incredibly low, allowing researchers to vividly see the potential benefits of L-Carnitine supplementation for patients with lesser deficiency. The researchers who conducted this study came to the ultimate conclusion that L-Carnitine supplementation has the ability to reduce body fat, increase muscle mass, and improve capacity for physical and cognitive activity by reducing the effects and severity of exhaustion and fatigue.

L-Carnitine Supplementation a Smart Decision

L-Carnitine is a vital part of a healthy diet and helps maximize physical and mental health. Although our body can naturally produce a certain level of L-Carnitine, it is necessary to eat foods or take supplements which contain L-Carnitine in order to maximize the benefits of the hormone. L-Carnitine is a legal supplement which can be purchased at nearly all nutrition stores. A normal and healthy dose of L-Carnitine is generally between 2 and 4 grams of L-Carnitine per day, which is around the dose provided to the patients in the study discussed above.

L-Carnitine Important for Individuals of All Ages

Although the above study is related to the use of L-Carnitine in geriatric patients, it displays the importance of maintaining a healthy level of L-Carnitine throughout one's life. Healthy levels of L-Carnitine are necessary in order to maximize the benefits of cardiovascular training because it helps the body maintain the necessary level of energy in order to engage in strenuous exercise.

The hypothesis of the researchers in the above study, that L-Carnitine is necessary to sustain ATP levels optimally over time, shows that fatigue and exhaustion are physical disorders related to the energy available to the body at any moment in time. It is not just a matter of the brain or the muscles' ability to withstand pressure, but fatigue is directly related to the rate at which the body uses up internal energy sources such as ATP.

L-Carnitine increases the Benefits of HGH

Both L-Carnitine and Human Growth Hormone are intricately related to the metabolic processes which enhance exercise ability and increase our ability to withstand physical exertion. L-Carnitine helps the body use every ounce of energy with maximum efficiency, whereas Human Growth Hormone releases internal stores of energy which provide the muscles of the body with additional energy to further enhance exercise capacity. L-Carnitine and Human Growth Hormone play unique yet inextricably linked roles in physical performance, and both HGH Deficiency and L-Carnitine Deficiency prevent individuals from achieving optimal energy levels and sapping men and women all over the world of their vitality.

Human Growth Hormone and L-Carnitine are fantastic when taken together. L-Carnitine is a vital protein that the body absolutely has to have to survive, but it is in no way a substitute for Human Growth Hormone. HGH is a vital hormone which promotes metabolism throughout the body, whereas L-Carnitine simply maximizes the effectiveness of available energy. In terms of physical performance and energy, think of HGH as an energy excavator and think of L-Carnitine as an agent of efficiency.

L-Carnitine Supplementation

What Forms of L-Carnitine Supplements are Effective?

L-Carnitine is available in a number of forms and, for the most part, the protein remains intact through the process of digestion. L-Carnitine can be commonly found as a liquid, hard tablet, or powder capsule. There are a number of options available and you are free to choose which works best for you. For patients who are significantly deficient in L-Carnitine, it is possible to receive an L-Carnitine injection from a physician via prescription.

Do Not Take Too Much L-Carnitine

We do not suggest taking a dose of L-Carnitine greater than 4 milligrams per day without the approval of a qualified physician, because there are certain risks involved with L-Carnitine overdose. L-Carnitine overdose can cause stomach problems such as cramping, nausea, vomiting, and diarrhea. Overdose of L-Carnitine can also lead to elevated levels urea in the blood which can actually hinder exercise performance and cause muscular weakness.

Natural Sources of L-Carnitine

In addition to taking L-Carnitine in supplemental form, there are also many great sources for the vital protein that you can find in your every day diet. Red meats are a significant source of L-Carnitine, although they should be eaten sparingly if at all in any diet. For individuals who are not lactose-intolerant, Milk products are a great source of L-Carnitine. L-Carnitine deficiency is a fairly common occurrence among vegans and vegetarians for this reason.

For individuals who desire to limit red meat consumption and are lactose intolerant, there are a number of fruits and vegetables which provide L-Carnitine, including bananas, apricots, kale, parsley, okra, mustard greens, garlic, collard greens, Brussels sprouts, broccoli, and asparagus. Seeds and nuts also contain a healthy dose of L-Carnitine as well. Whole wheat, rice bran, oatmeal, corn, and rye contain L-Carnitine, but remember to avoid processed rice and grains when possible.

L-Carnitine as a Medical Treatment

There are a number of medical conditions for which L-Carnitine supplements and injections are recommended and/or prescribed. Some individuals have a genetic disorder which limits their ability to process their own L-Carnitine. Certain medical treatments such as hemodialysis can lead to L-Carnitine Deficiency as well. L-Carnitine supplements are an important thing to consider when starting a diet, because making a significant dietary transition can often lead to insufficient ingestion of certain nutrients such as L-Carnitine.

L-Carnitine is also a common supplement used during treatment of cardiovascular complications. L-Carnitine has been shown to alleviate cholesterol levels and decrease risk of heart attack, heart failure, and stroke. The protein has also been shown to relieve certain issues arising from poor circulation in the extremities.

L-Carnitine Reverses Muscle Atrophy

L-Carnitine supplementation is often recommended for AIDS patients in order to alleviate the symptoms of muscle wasting associated with the immune virus. L-Carnitine helps prevent the human body from feeding on its own musculature, which helps AIDS patients and has also been used to preserve health in patients in recovery from anorexia as well. For men who are having fertility trouble, L-Carnitine is often an early suggestion for encouraging procreative ability.

For patients too young to suffer from HGH Hormone Deficiency, L-Carnitine is a useful method of safely and legally optimizing endurance and physical performance. If you do suffer from HGH Hormone Deficiency or Testosterone Deficiency, L-Carnitine is one of the many nutrients that you will need to maximize the benefits of your treatment.


L-Carnitine and Bone Mass

As we age, L-Carnitine levels in the cells start to decline. This negatively impacts the metabolism of fatty tissues throughout the body. The bones are significantly affected by this metabolic decline. The bones are slowly but constantly undergoing a process known as remodeling and organs known as osteoblasts require adequate metabolic activity to perform their function of restructuring bone. Without sufficient osteoblast activity, the bones are slowly leeched of their calcium and an overall reduction in bone capacity will eventually result in osteoporosis.

L-Carnitine Provides Antioxidant Benefits

L-Carnitine is one of a large group of nutrients and supplements known as antioxidants. Antioxidants protect the body at a cellular level from elements known as free radicals. Free radicals are rogue atoms and molecules that lack an electric charge and can damage human cellular bodies. The purpose of antioxidants are to cancel out the potential damage caused by free radicals. When individuals lack sufficient antioxidants, these rogue elements and molecules take control and break down organs at a cellular level. L-Carnitine Deficiency is common in geriatric patients and, as a result, these patients are more at risk of cellular damage as a result.

Pharmaceutical Uses for L-Carnitine

L-Carnitine and the Heart

Clinical research has proven that L-Carnitine can be beneficial for patients that have suffered from angina. L-Carnitine supplementation reduces the need for certain medications and also increases energy and reduces fatigue while helping prevent further occurrences of chest pain. Some clinical studies even present evidence that L-Carnitine can help those that have suffered a heart attack from experiencing another. L-Carnitine can also prevent angina after a heart attack and can preserve normal heart rhythm, which may prevent the need for a pacemaker. There is not definitive evidence regarding these final claims as of yet, however.

L-Carnitine and Kidney Disease

The kidneys are one of the primary organs which create endogenous L-Carnitine. Patients who suffer from kidney disease almost universally suffer with issues with L-Carnitine production. Patients who undergo dialysis as a result of kidney disease are often prescribed L-Carnitine in order to maintain energy levels and reduce symptoms of fatigue related to kidney disease and its treatment.

L-Carnitine and Male Fertility

L-Carnitine Deficiency can lead to fertility issues in males. Sperm cells are one of the kinds of cells which most rely on L-Carnitine in order to function optimally. With insufficient L-Carnitine, sperm quality declines and the sperm are often not active enough to ensure insemination. L-Carnitine has also been proven beneficial in treating a disorder known as varicocele, which is a vascular disorder which disrupts the functional ability of the testicles. Evidence even suggests that L-Carnitine supplementation even outperforms surgery in the treatment of this disorder.

L-Carnitine and Weight Loss

Those who are interested in weight loss would be smart to use L-Carnitine as a dietary supplement. L-Carnitine is often labeled as a weight-loss treatment, but this is not quite an accurate assessment of what L-Carnitine can achieve. There is evidence that L-Carnitine can improve BMI by decreasing adipose fat while boosting muscle mass, but this may not result in overall weight loss. L-Carnitine in this respect can be understood more as a mechanism for body sculpting than for the encouragement of weight loss.

For patients with Human Growth Hormone Deficiency, Bio-Identical HGH injections vastly outperform L-Carnitine in the treatment over obesity, although L-Carnitine does produce many positive benefits regarding cardiovascular and metabolic health. It is important to think of L-Carnitine as a supplement which can increase the effectiveness of various forms of Hormone Replacement Therapy rather than a fully-fledged treatment option in and of itself.

L-Carnitine and Muscle Developmental

Clinical research has proven that L-Carnitine significantly improves muscle development and function. One study shows that L-Carnitine supplementation can even help healthy individuals increase muscle mass and reduce fatigue associated with exercise. Of course, until research suggests otherwise, it is important to limit L-Carnitine consumption to no more than 4 grams per day. As the body loses the ability to produce its own L-Carnitine with age, the benefits of L-Carnitine supplementation continue to become more and more pronounced.

L-Carnitine Can Benefit Patients with Mild to Moderate Asthmatics

Studies are beginning to show that some forms of asthma may be the result of L-Carnitine Deficiency in youth. In comparison to healthy children, kids with mild to moderate chronic asthma were shown to have comparatively lower levels of L-Carnitine. L-Carnitine has been shown to be a useful and successful treatment option for a significant portion of children with this form of asthma. L-Carnitine is thought to improve metabolism in cells within the lungs which helps the organ to absorb oxygen more efficiently, often reducing and eliminating the need for an inhaler.

L-Carnitine and Hyperthyroidism

Hyperthyroidism is the result of an overactive thyroid gland. Symptoms of hyperthyroidism include fatigue, insomnia, muscle atrophy, weight loss, and anxiety. There is clinical proof that hyperthyroidism pulls L-Carnitine from the body and impoverishes cells throughout the body from healthy L-Carnitine levels. There is significant evidence that L-Carnitine supplementation can alleviate and reverse many symptoms of Hyperthyroidism. L-Carnitine is secondary to hyperthyroidism and does not prevent hyperthyroidism, but can alleviate symptoms when they occur.

L-Carnitine is an Important Part of any Health Regimen

L-Carnitine is a potent metabolism-enhancing protein which can provide significant benefits throughout the body. Many Anti-Aging Hormone Panels include testing for L-Carnitine Deficiency. This test will help your physician optimize your Hormone Replacement Therapy Regimen, providing you the greatest possible benefits.

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01 October 2017

Restrict your calories 30% and live 30% longer?

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The Theories of Caloric Restriction and Aggressive Supplementation

Do shortcuts exist to a longer life?

There are many people that believe that there are. One older couple feel that they have realized the key to longevity, and they are dedicating their lives to testing the hypothesis. Paul McGlothin, age 60, and Meredith Averill, age 61, have been following a strict regimen of caloric restriction over the last fourteen years in an attempt to prove that the technique produces enhanced life expectancy.

What is Caloric Restriction?

Caloric Restriction is a form of diet in which an individual consumes a lower than average number of calories in an attempt to increase overall health and life expectancy. It is based on the assumption that as long as we meet basic physiological needs through human diet, the fewer calories we eat per day, the longer that we will live as a direct result.

There is a significant amount of evidence which correlates caloric restriction and life extension in animals, but studies are just beginning to take place examining this phenomenon and how it may relate to human beings. McGlothin and Averill are the inspiration for one of these human studies, and are active participants in one of those studies as well. Washington University Researchers are monitoring the couple in order to investigate the potential benefits of caloric restriction in human beings. This study is one of the first three of its kind ever conducted.

In order to maximize the effectiveness of their diet, they only consume certain foods which are loaded with nutrition, while also being low in caloric content. These diets consist largely of fruits, vegetables, and greensand proteins are consumed relatively sparingly. They and other participants in this study keep total track of the food that they consume. The couple have shown that they consume around nine percent of their calories from protein, thirty two percent from fat, and fifty nine percent from carbohydrates.

During every possible meal, the participants in this study weigh the food that they consume and maintain detailed digital records of the calories and nutrition that they eat and drink. Participants log into a computer program known as the Cron-O-Meter in order to post their daily results. McGlothin consumes around 1,900 calories per day, and Averill eats around 1,500 calories. These amounts are around 1/3 less than what the average American male and female consume, respectively. Although the couple are noticeably thinner than average, they maintain BMIs of 18, which are considered normal for men and women their age.

McGlothin and Averill are convinced that the benefits of their monitored diet plan are astounding. The couple have authored a book titled The Caloric-Reduction Way as a means to express to the public their lifestyle tips and their dietary choices in order to spread their life-changing knowledge to a wider audience.

Averill has been told by doctors that her heart and cardiovascular system are structured like a woman many decades younger than herself. Her husband says that caloric restriction, as it is engaged in by he and his wife, produces incredibly positive effects on all manners of physical function. McGlothin is sixty years old and says that he has perfect vision. In addition to this, he has performed exceedingly well on cognitive tests, and his scores have actually improved as he enters his sixties, when among most people, the opposite occurs and the mental faculties slowly begin to deteriorate. He laments that his old chess buddies just dont have the ability to keep up any longer.

Caloric Restriction in the Animal Kingdom

Gerontologist Robert Butler was a psychologist profoundly concerned with gerontology and reducing the suffering and pain caused by the aging process. He coined the term Ageism in order to highlight the unfair treatment of the elderly by the generations that proceed them. The concept of ageism, Butler believed, was the reason why scientific understanding of the latter part of the aging process was so understudied and thus misunderstood.

Butler is also well-known for spearheading the belief that senility is not an inevitability of the aging process, thus opening the door for Anti-Aging and Longevity science. Butler was the founder of the International Center for Longevity, and was an important force in the group until his death in 2010 of leukemia at the age of 83.

Doctor Butler says that caloric restriction has produced the ultimate effect of life expectancy extension in nearly every animal ever studied. It has been shown that a thirty percent reduction in caloric intake has been connected to a thirty percent longer life. Butler understands that there are normally certain limits when attempting to relate animal research studies to humans, because animal and human physiology can be quite different. This particular case produces stronger evidence, however, because the same results are being produced all throughout the animal kingdom. Although we are likely to differ from a single animal, we are much less likely to differ significantly from all animals as a group, Butler strongly believes.

A recent study conducted with monkeys provides the strongest evidence yet that Humans can benefit from caloric restriction. Caloric restriction has produced evidence that monkeys who are put on this diet live healthier lives. Butler does admit that there are a couple of drawbacks, however. Caloric Restriction has the potential to lead to both decreased libido and overall energy. Also, there is the issue of compliance. Many people simply dont have the willpower or patience for a restricted-calorie diet. For these individuals, however, there is a chemical being researched known as resveratrol which may have the capability to reduce the desire to over-consume food and thus make living by a more restrictive diet a simpler proposition.

Supplements and Nutrition

Of course, there are other strategies used to enhance longevity as well. Doctor Grossman is the executive director of Denvers Grossman Wellness Center. He believes that the key to a longer life is to engage in a long-term regimen that includes a healthy and nutritious diet, anaerobic strength training, cardiovascular exercise, and meditation or other forms of stress reduction. Dr. Grossman emphasizes prevention, and he begins his patients initial treatments with a two day battery of complete medical testing.

Dr. Grossmans team runs a comprehensive testing program in order to unearth underlying hereditary diseases and predispositions that have the potential to effect longevity. In addition to this, the doctor works with his patients in order to diagnose underlying health disorders and build a profile of the hereditary history of family disease. Dr. Grossman uses all of the information provided to him through testing and uses the results in order to provide medications and supplements that work to optimize the health of his patients.

Grossman has teamed up with a man named Ray Kurzweil in order to co-author a book about the future of longevity and Anti-Aging titled The Fantastic Voyage. Kurzweil is sixty years old, and is a highly regarded inventor and scientist. Among the list of prestigious recognitions he has received is the National Medal of Technology. Kurzweil is currently serving in a top level technological position with Google, attempting to create programs that enhance the learning capability and speech recognition of computers.

Kurzweil and Grossman believe that living a healthy lifestyle can only do so much to enhance the lifespan, and that the aggressive use of supplements is an important step in slowing down the process of aging, in addition to living a healthy lifestyle.

Kurzweil aggressively utilizes nutritional supplementation. At one time in his life he claims that he utilized over 250 supplements in order to attempt to optimize his own health. Today, he has whittled that number down to 150. He is confident that without this aggressive use of medical supplementation, he would not be as healthy as he is today. Mr. Kurzweil undergoes a regular hormone profile every three months in order to monitor his nutrient levels.

Using this testing as a guideline, he engages in this extreme form of supplementation in order to maximize his nutritional intake. In addition to this supplementation, he drinks ten cups of green tea and ten glasses of alkaline water each day. He claims that the hormone and nutrient levels in his body are the equivalent of a man twenty years younger than himself. He urges that this sort of supplementation should only be done with regular monitoring, so that an individual can adjust to changing physiological conditions within the body.

The majority of the supplements and nutrients that Kurzweil uses will be quite familiar to you, because they are an essential part of every diet, such as the common minerals and vitamins. Many others, however, are much more obscure, such as phosphatidylcholine, which the inventor claims has the ability to maintain cell membranes and prevent them from aging. Phosphatidylcholine is a phospholipid which is contained within every cell membrane of the human body. Studies have shown that this phospholipid is likely beneficial to the liver, but there is little evidence for Kurzweils use of the substance.

A Counterargument

Although Kurzweil is incredibly confident in his endeavour, there are certainly detractors, such as University of Chicago School of Public Health Professor Jay Olshanksy. Professor Olshanksy feels that the overuse of supplements is a waste of both money and time. He feels that for most individuals who utilize this sort of aggressive supplementation, there is minimal benefit outside of placebo, and the majority of the supposed nutrients consumed are simply eliminated during urination and never make their way effectively to the blood stream.

Three things that everyone agrees on is that everyone should eat healthy, engage in exercise, and take measures to alleviate stress. Although there is a lot of evidence which suggests that methods such as supplementation and caloric restriction can have a positive effect on life expectancy, it will be a long while before enough evidence accrues that we know for sure.

How does all this relate to the Conscious Evolution Institute?

The paths of both Paul McGlothin and his wife, and Ray Kurzweil converge in many ways in our Hormone Replacement Therapy Treatment Plan. We do believe in the use of caloric restriction. The caloric intake of Mr. McGlothin and his wife are right around what we believe is ideal for both sexes. Although Paul and his wife may be in good health for their age, to look at them, one can still see that time is taking its toll upon them. We feel that if they combined their unique diet with Hormone Supplementation, they would benefit much more.

We also believe that supplements and proper nutrition are vital to a healthy body and healthy hormones, as does Mr. Kurzweil. We believe that Mr. Kurzweil almost certainly over-utilizes many supplements, however. Just think of the expense of taking 150 separate supplements simultaneously. He has also been accused of using many supplements that have been proven ineffective by the scientific community. We at the Conscious Evolution Institute are forward thinking and attempt to stay ahead of the curve while also remaining grounded in legitimate medical science.

Even though we may view Mr. Kurzweil with a tinge of scepticism, we recognize that in doing so much, he is likely making many of the correct decisions as well. We do not share the pessimism of Aging researchers such as Olshansky who are unable to foresee the amazing changes in Longevity medicine just over the horizon. By constantly researching new therapies, yet remaining grounded in a base of traditional medical theory, we are able to pick and choose the most effective breakthrough anti-aging theories before they become common techniques.

The Best of Both Worlds

Our form of Longevity Therapy centers on hormone restoration and optimization rather than full nutrient overload. There is a very high likelihood that Mr. Kurzweils therapy is quite successful, but we also believe that he is likely spending a lot of money on supplements that do not work well, and more money on others that dont work at all. Ray Kurzweil is a wealthy and wildly successful inventor, so he has the discretionary income to take significant chances in order to maximizing his health.

The process at the Conscious Evolution institute is streamlined, and the majority of the cost comes from the purchase of Bioidentical Hormone Replacement Therapy, not raiding the local General Nutrition Center. Human Growth Hormone and Testosterone HRT have decades of research showing the multitude of benefits of hormone replacement.

We urge you to take the theories presented in this article to heart, but take them with a grain of salt as well. We are certain that if you research the impressive benefits of Hormone Replacement Therapy, you will be convinced that it provides the best opportunity to maintain health and vitality, especially HGH and Testosterone Treatments are combined with proper nutrition and smart lifestyle choices.

http://abcnews.go.com/Health/Longevity

05 January 2013

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Knowing Two Languages Can Postpone DementiaKnowing two languages can postpone dementia
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