Frequently Asked Questions About Sermorelin Acetate Therapy

Sermorelin Frequently Asked Questions

This article aims to help you become better informed about a new form of Hormone Treatment known as Sermorelin Acetate Therapy.

This article serves as a reference point to help you become more knowledgeable about this highly beneficial therapy.

Question: What is Sermorelin Acetate?

Answer: Sermorelin Acetate is a hormone derivative that spurs the natural secretion of endogenous Human Growth Hormone by the pituitary gland. Sermorelin Acetate is the functional equivalent of a hormone produced by the hypothalamus known as Growth-Hormone Releasing Hormone. GH-RH is also often referred to as Growth Hormone Releasing Factor.

Although Sermorelin and GH-RH are not biologically identical, they are functionally identical, meaning that the two molecules produce the exact same effects in the human body, despite being arranged in different configurations.

Sermorelin and GH-RH share the same initial sequence of amino acids, but Sermorelin Acetate is truncated, meaning that the hormone sequence is cut short.

Scientific researchers found that by producing a bio-synthetic hormone that only contains the first twenty-nine amino acids of Growth Hormone-Releasing Hormone, they could create a potent medication that is cheaper to produce while maintaining the exact same medical effect on the human body.

Sermorelin Acetate was isolated and invented by Nobel Prize Winners Andrew Schally and Roger Guillemin. The chemical configuration of GH-RH is referred to as GRH 1-29 NH 2. GRH 1-29 is the active sequence of Growth Hormone-Releasing Hormone. The NH-2 refers to a closing sequence which is inert and serves to tie off the end of the molecule.

Question: What is the difference between Sermorelin Acetate and HGH?

Answer: Many people get this somewhat confused, thinking that Sermorelin Acetate increases internal levels of Human Growth Hormone; Sermorelin is actually a form of HGH. This is untrue. Sermorelin is a hormone that scientists label a secretagogue.

Secretagogues are hormones produced by the brain which stimulate other hormones to be produced. They serve as intermediary messengers which move the message along to target organs and tissues in the rest of the body.

GH-RH is released by the pituitary gland and flows through a series of blood vessels in the brain known as the epiphyseal portal system. Upon reaching the Anterior Pituitary Gland, Growth Hormone Releasing Factors stimulate organs known as somatotrophs within the pituitary to manufacture and secrete Human Growth Hormone to circulate to the liver and other organs. Sermorelin Acetate imitates the function of GH-RH, producing a biologically identical response when it reaches the somatotrophs.

Sermorelin is a much smaller hormone than both GH-RH and Human Growth Hormone. Sermorelin contains 29 amino acids, whereas GH-RH contains 45. HGH dwarfs both of these hormones in size, as it is comprised of 191 amino acids!

Question: Health Stores and Online Websites often advertise Human Growth Hormone Releasers supplements. These supplements are available over the counter and do not need a prescription. Are these supplements similar to Sermorelin?

Answer: Absolutely not. Supplemental HGH Releasers are most often component amino acids that comprise Human Growth Hormone, including L-Dopa, Glycine, L-Ornithine, L-Glutamine, and L-Arginine.

Other chemicals are marketed as HGH Releasers, including Tribulus Terrestris, Macuna Pruriens, and Ornithine Alpha-Ketoglutarate.

These amino acids stimulate HGH production, but they are unhealthy for the body and do not produce a strong enough benefit to warrant the risk. HGH Releasers work (if they genuinely work) by increasing overall activity throughout the brain.

This increased activity level does have a slightly stimulative effect on Human Growth Hormone Levels, but it also stimulates other positive and negative activities throughout the brain.

HGH Releasers Do Not Work As Advertised

Many medications labeled as HGH Releasers are entirely ineffective, veritable snake-oil products. Supplements are not certified for effectiveness in the same way as medications such as Sermorelin Acetate and Bio-Identical Human Growth Hormone, so there is not necessarily a proven or guaranteed medical benefit to using the supplements.

At best, HGH Releasers stimulate a Growth Hormone release that is just about equivalent to exercise, and at worst, you'll damage your liver and experience no benefits.

Also, Growth Hormone Releasers produce incredibly unreliable effects because different areas of the body and brain may experience different response levels every time you take the pill. High Doses of Growth Hormone Releasers can lead to liver and kidney issues, as the human body cannot process extremely high levels of unprocessed amino acids without accumulating damage in the filtering and processing organs of the human body.

Sermorelin Acetate produces natural and beneficial effects with minimal risk of side effects. Sermorelin Acetate Therapy has an incredibly safe track record and has been proven effective at treating Adult-Onset HGH Deficiency.

Question: I've read a bit about Human Growth Hormone Replacement Therapy, and it seems to be perfectly capable of resolving issues surrounding HGH Deficiency and Hypopituitarism. What would make me choose Sermorelin Therapy over Bio-Identical HGH?

Answer: There are some reasons why a patient would choose Sermorelin Acetate over Recombinant Growth Hormone, although both certainly have their place as treatment options.

HGH and Sermorelin can produce the same exceptional benefits to the human body, but they also share some profound differences.

Sermorelin Imitates Normal Physiological Processes

First, Sermorelin Acetate functions in a manner that is more streamlined with the actual function and overall needs of the human body. When you use Growth Hormone HRT, there are no safeguards that protect the body against accidental overdose.

Any Human Growth Hormone injected into the body directly cycles through the liver and the body and stimulates the body. Sermorelin, on the other hand, as a Growth Hormone Secretagogue, can be affected by processes known as Negative Feedback Mechanisms.

Harmful Feedback Mechanisms kick in when the body signals to the brain that Human Growth Hormone Secretion has satisfied the body's needs.

After receiving these signals, somatostatin hormones block GH-RH and Sermorelin from reaching the Pituitary, preventing the excess secretion of Growth Hormone.

Because Sermorelin works according to the standard physiological rules of the human body, it is almost impossible to overdose on Human Growth Hormone via Sermorelin Injection. Other patients may choose Sermorelin Acetate to avoid the temptation to overdose on or abuse HGH.

Sermorelin Releases Episodic HGH

Another benefit that Sermorelin Acetate Injections have over Human Growth Hormone Injections is that they are processed by the body in different patterns. Although HGH and Sermorelin ostensibly accomplish the same goals, Human Growth Hormone Injections supply a relatively constant level of HGH Release over time, which is not actually how the body produces Human Growth Hormone.

HGH Release is categorized by a function known as Square Wave release. Square Wave means that HGH concentrations rise to a peak during the course of the day, plateau, and drop back down to baseline. This can cause a problem over time, inducing a medical response known as Tachyphylaxis.

Tachyphylaxis can be understood most simply as a decrease in sensitivity due to outside pressures. The body can sometimes slowly recognize that HGH is being provided by an outside source, and the body builds resistance as a response.

Sermorelin releases Human Growth Hormone via an episodic pattern that more closely resembles the natural pattern of release by the human body. The pituitary only releases Human Growth Hormone when the body is ready for it, thus significantly reducing the threat of internal resistance to increased levels of HGH.

Sermorelin Preserves the Normal Hormonal Equilibrium

The third benefit of Sermorelin Acetate, related to the second, is that Sermorelin Acetate more appropriately preserves the Neuroendocrine Axis. The Neuroendocrine Axis is the cascade of hormones released throughout the body.

Simply put, all hormones released by the human body have a particular impact on the release of other hormones. Injecting HGH directly into the body daily can suppress its natural ability to produce its own Human Growth Hormone, which can affect the release of other hormones.

Sermorelin Acetate makes less of a physiological imprint on the endocrine system, meaning that it more naturally resolves hormonal deficiency while causing minimal impact on the normal function of other hormones and systems of the body.

Sermorelin Available for Off-Label Use

A fourth and final benefit of Sermorelin Acetate is less physiological and more technical. Sermorelin Acetate Hormone Replacement Therapy is not as tightly regulated as Human Growth Hormone Replacement Therapy. The FDA prohibits using Human Growth Hormone for off-label uses, whereas Sermorelin Acetate can be used off-label at the discretion of the prescribing physician.

Question: I understand that Human Growth Hormone can only be delivered via Injection. Is this also true for Sermorelin Therapy?

As of 2013, Subcutaneous Injection is the only effective method to administer Sermorelin Acetate. Like, Human Growth Hormone, the Sermorelin Acetate molecule is too large to breach other barriers of the human body at this date.

On the bright side, since Sermorelin is significantly smaller than Bio-Identical HGH, there is a hypothetical chance that Sermorelin may one day be administered by breaching the mucous membrane barrier using a nasal spray. This method is currently being tested and may be effective at some point shortly.

Question: Do Sermorelin and Human Growth Hormone Injections require similar doses to be effective?

Answer: Even though HGH and Sermorelin activate in different body regions (Sermorelin in the anterior pituitary, Human Growth Hormone in the liver), the volume of hormone that is required to sufficiently increase endogenous IGF-1 production is nearly identical.

Human Growth Hormone is most commonly prescribed at doses that vary between one and two international units.

Sermorelin Acetate is generally administered with a dose of two hundred micrograms daily.

Question: How much does Sermorelin cost in comparison to HGH?

Answer: Per vial, Sermorelin is cheaper than Human Growth Hormone. In addition, a single vial of Human Growth Hormone takes twelve to fourteen days to administer fully, whereas a single vial of Sermorelin takes fifteen days to utilize fully.

Question: In many patients, the benefits of Human Growth Hormone start to fade over the course of continual use. Why does this happen, and does Sermorelin lose potency as well?

Answer: The human body can develop a resistance to HGH Hormone Replacement Therapy over time. If this has occurred to you, the change in effectiveness is not the result of any inadequacy of the medicine itself. Human Growth Hormone Injections increase serum levels of Growth Hormone to levels that are higher than usual for many hours every day, although the average release across the day is medically appropriate.

HGH Up-Regulation and Sermorelin Down-Regulation

In addition, Human Growth Hormone Therapy leads to a stable release of IGF-1 throughout the body, slowly rising and falling in the body through the course of the day. This causes the body's tissues to have a steady supply of IGF-1 throughout the day, rather than receiving the hormone in the regular bursts to which it is accustomed.

As a result, the IGF-1 receptors in the tissue tend to go through a hormonal process known as down-regulation to preserve normal function. This means that the target tissues become desensitized to IGF-1 and Human Growth Hormone exposure, reducing the effectiveness of the hormone treatment.

When the body is functioning normally, Human Growth Hormone is released naturally from the pituitary gland in short, brief, and potent bursts, which supply the body with sufficient levels of IGF-1 and Human Growth Hormone while also giving the receptors time to rest between periods of hormone release.

If outside hormone release properly imitates the natural processes of the body, this gradual down-regulation does not occur, and the benefits of increased HGH production do not decline in the same manner over time.

Because of the influence of Somatostatin described above, Sermorelin Administration only leads to the optimal release of Human Growth Hormone. Sermorelin can make the pituitary stronger through a process of up-regulation which strengthens its health by increasing the level of HGH it produces daily.

Question: Does Sermorelin Acetate provide any benefits for patients suffering from Adult-Onset HGH Deficiency that are not directly related to its effect on the endocrine system?

Answer: Yes. A large body of evidence shows that Growth Hormone-Releasing Hormone and Sermorelin Injections directly can increase sleep quality and promote the experience of the deepest stages of sleep, which are the most rejuvenative and beneficial to health and wellness.

Question: What is the standard administration protocol for Sermorelin Hormone Therapy?

Answer: Sermorelin is delivered once each day via injection. Sermorelin usually is administered just before bed to mimic the natural hormone production of the body more closely. Sermorelin is intended to supplement the body's own natural production of Growth Hormone-Releasing Hormone, which occurs primarily at night.

The Sermorelin Dosage for the patient  will depend upon the individual's physiological needs. Sermorelin Shots are provided in vials that contain multiple doses. The vial will contain enough Sermorelin to treat the patient for at least fifteen days.

The Conscious Evolution Institute

If you have any other questions about Sermorelin Acetate, Human Growth Hormone Shots, or any other hormone treatments, we would be happy to provide you with answers to questions you may have.

Different patients respond differently to treatment, and some patients respond more actively to Human Growth Hormone Replacement Therapy than Sermorelin Acetate.

If you choose the Conscious Evolution Institute, our knowledgeable and top-of-the-line staff of physicians and longevity specialists will help you decide which treatments are right for you!

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